Production of HGH
Human growth hormone consists of a single chain of 191 amino acids. It is made in the brain but secreted in the bloodstream.
Its production is controlled by a complex set of hormones, mainly growth hormone-releasing hormone (GHRH) produced in the hypothalamus, somatostatin that is produced in various tissues throughout the body, and ghrelin, which is produced in the gastrointestinal tract.
The pituitary puts out HGH in pulsatile bursts that vary hourly. Higher daily hGH levels are seen after exercise, trauma, and sleep. Peak highest levels are reached at night. In general, HGH levels are increased in childhood, spike to their highest levels during puberty, and subsequently decrease as one ages.
Human growth hormone (hGH) is a naturally occurring hormone produced by the pituitary gland. It’s important for growth, cell regeneration, and cell reproduction.
HGH helps to maintain, build, and repair healthy tissue in the brain and other organs. This hormone can help to speed up healing after an injury and repair muscle tissue after exercise. This helps to build muscle mass, boost metabolism, and burn fat.
HGH is also said to benefit the quality and appearance of the skin. It’s said to slow down the aging process and treat age-related diseases. However, research supporting these claims is limited.
HGH works by stimulating metabolic processes in cells to activate metabolism. It stimulates the liver to make an insulin-like protein that produces cartilage cells. This plays a part in bone and organ growth, as well as muscle protein synthesis.
Although hGH is a naturally occurring substance, it’s also available in synthetic forms as a treatment or supplement. But what are the risks of taking it?
Read also about Gonadorelin injections
Function of HGH
HGH is mainly involved in two processes—growth and metabolism. HGH stimulates bone and cartilage growth, especially during periods of rapid growth during childhood.
Cartilage-forming and bone-forming cells called chondrocytes and osteoblasts receive signals to increase replication and thus allow for growth in size via HGH’s activation of the mitogen-activated protein (MAP) kinases designated ERKs (extracellular signal-regulated kinases) 1 and 2 cellular signaling pathways.
Activation of this phosphorylation intracellular signaling cascade results in a cascade of protein activation, which leads to increased gene transcription of the affected cells and ultimately causes increased gene replication and cellular growth.
Simultaneously, HGH upregulates insulin-like growth factor 1, which causes cells to increase amino acid uptake, protein synthesis, and decrease catabolism of proteins. This is the anabolic state.
HGH also mitigates insulin’s ability to take up glucose in the muscles and peripheral tissues. This causes more glucose to remain in the blood and an increased rate of gluconeogenesis by the liver.
User Reviews of HGH
John·Taken for 2 to 5 years·May 15, 2017
Omnitrope (somatropin): “A very large meningioma next to my pituitary gland damaged the pituitary and lessened the production of several hormones including growth hormone. This is a rare disorder and I had difficulty finding an endocrinologist who could diagnose the problem much less know how to treat it but was finally successful in finding a doctor who diagnosed my problem and prescribed Omnitrrope for me. After taking the medicine for four days my strength improved considerably. That was three years ago and I continue to use the medicine. I am confident it saved my life.”
Feeling Better·September 20, 2009
Humatrope (somatropin): “This works quite well for me. I don’t know if anyone else uses it or had adult onset growth hormone deficiency and also developed this condition from Gulf War Syndrome. When I started taking the Humatrope, my bone density went from a -4 to a -2.3 and hopefully is still going up. My focus and concentration improved and my irritability and my energy level went way up! I have been using it for about 5 years now and didn’t know I had it until my urologist started listing reasons for severe osteoporosis and it turns out that I had adult onset growth hormone deficiency. Good luck to all. Hopefully Stem Cell technology can be used to help cure/fix us!”
Mike·February 25, 2009
Saizen (somatropin): “I’m 70 and seemingly in EXCELLENT health. NO pains or problems with ANYTHING. I work on my estate daily and have better energy than my younger by far workers. Before I started taking human growth hormone (HGH), I found that my skin was growing very thin and becoming a slight pinkish blue. Now this is completly resolved. I go to a life extension doctor that after testing found that my hormones like all older persons were low so I’m now supplementing with HGH, Pregnalone, DHEA, and Testosterone (transdermal. I highly recommend it to my friends and acquaintances and to you to have your blood tested.”
jemay·Taken for 1 to 6 months·August 3, 2015
“I was skeptical at first but after taking this product for 60 days I have to say I’m amazed at the results! I’ve definitely seen a decrease in fat that was near impossible to get rid of and have become much more cut. I slept better, felt better, and just felt younger again. I’m 38 and was starting to feel “old.” I’m definitely a fan! This stuff actually works. I feel stronger, have more energy and have started to lose weight. It takes about a couple of weeks to make a noticeable difference but you will notice it once you start to pay attention to what is going on. Great Products! admin is it okay to add other hgh pills in my body? i just bought a product for my brother because he’s 42 years old and I want to try it to my”
John·Taken for less than 1 month·August 19, 2019
“I am only a week into GH (growth hormone) therapy, taking .75 IU/day. My energy has increased somewhat, and I have noticed an improvement in cognitive functioning. However, I can’t sleep. On Thursday night – 2 hrs, Friday – 2.5 hrs, Saturday – 1 hr nap, 2.5 hrs, and Sunday (last night) – 2.5 hrs. I have been taking injections in the morning. This morning, I only took 1/3 of my injection and am going to take the other 2/3 tonight so that I can try taking it before bed. Hopefully, I will see some improvements.!”
Broke·Taken for 1 to 2 years·January 3, 2020
Humatrope (somatropin): “This medicine works great. My problem is the price! I qualified for the humatrope card that helps with the 28day cost. I have insurance and the cost is VERY HIGH! My part after insurance is almost $200 every 28 days. I am allowed $2400 for 24 months. I ran out of that benefit amount in October. I had to pay $200 every 28 days for the remainder of 2019. Now that it is January 2020 they said I only have 10 more months of assistance. ”
Collin·September 24, 2011
Norditropin (somatropin): “Nordotropin Flexpro Pen is very easy to use, just not easy to get the insurance company to approve or finding a Dr. that knows how to handle patients with this condition.”
189481pc·August 20, 2016
Humatrope (somatropin): “Tingling, itching and numbness of my hands. Sleeplessness leading to insomnia. Higher glucose numbers no matter the diet nearing diabetes.”
Summary
Human growth hormone (HGH or GH) sounds like what it suggests. It’s a hormone that helps humans grow, which is largely produced in the growth stage of life, peaking at puberty, then slowly declining later in life. HGH helps build, repair and maintain brain and organ tissue, build bones, and helps with cell growth and regeneration. It’s a vital hormone produced by the pituitary gland. If a child is deficient in HGH, a doctor may prescribe synthetic hormones so they can build strong, healthy bones and organs. Growth hormone deficiency is a rare condition but must be addressed.
As we get older, the production of HGH naturally slows, but it doesn’t affect us in the same way as children. Many people are turning to human growth hormone injections for its potential anti-ageing effect or to improve performance in the gym or with sports. Here, we share all the benefits and side effects of growth hormones to help you see the full picture of its use.